Discussion Forum : Alcohols Phenols And Ethers
Question -


Major product in Friedel-Craft's acylation of anisole is:-

Options:
A .   Chlorobenzene
B .   4-Chloro-1-methoxy benzene
C .   4-Methoxy-acetophenone
D .   3-Methoxy-acetophenone.
Answer: Option C
:
C
Friedel-Craft's acylation of anisole with acetyl chloride in presence of anhydrous AlCl3 gives 4-methoxy acetophenone(para) as a major product. Methoxy group in anisole is activating and ortho-para directing with major product being para isomer.

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