Antimicrobial And Chemotherapeutic Agents(Microbiology ) Questions and Answers

Question 1.  Which of the following is a drug that interferes with the process of DNA production in the virus that causes genital herpes?
  1.    Erythromycin
  2.    Vancomycin
  3.    Amantadine
  4.    Acyclovir
Explanation:-
Answer: Option D. -> Acyclovir
Question 2.  The most selective antibiotics are those that interfere with the synthesis of
  1.    bacterial DNA
  2.    bacterial RNA
  3.    bacterial cell walls
  4.    bacterial plasma membrane
Explanation:-
Answer: Option C. -> bacterial cell walls
Question 3.  Cycloserine inhibits
  1.    alanine racemase
  2.    D-alanyl - D-alanine synthetase
  3.    Both (a) and (b)
  4.    amidase
Explanation:-
Answer: Option C. -> Both (a) and (b)
Question 4.  Which of the antibiotic is not used as a food preservative ?
  1.    Pimaricin
  2.    Nisin
  3.    Tylosin
  4.    β-lactam antibiotic
Explanation:-
Answer: Option D. -> β-lactam antibiotic
Question 5.  Novobiocin can be used against
  1.    gram +ve Staphylococci
  2.    gram -ve Meningococci & Gonococci
  3.    Haemophilus
  4.    all of these
Explanation:-
Answer: Option D. -> all of these
Question 6.  Which antibiotic has a beta-lactam ring?
  1.    Cephalosporin
  2.    Penicillin
  3.    Tetracycline
  4.    Streptomycin
Explanation:-
Answer: Option B. -> Penicillin
Question 7.  Chemotherapeutic agents must
  1.    prevent/destroy the activity of a parasite
  2.    leave unaltered the host's natural defense mechanisms
  3.    be able to come in contact with the parasite by penetrating the cells
  4.    all of the above
Explanation:-
Answer: Option D. -> all of the above
Question 8.  
Interference mechanism of ciprofloxacin and norfloxacin is due to their action on
  1.    cell wall synthesis
  2.    cell membrane function
  3.    DNA function
  4.    protein synthesis
Explanation:-
Answer: Option C. -> DNA function
Question 9.  By which of the following means antifungal chemotherapeutic agents may affect fungi?
  1.    Interfere with nuclear division by preventing the aggregation of microtubules needed for mitosis
  2.    Interfere with normal nucleic acid synthesis
  3.    Interfere with ergosterol biosynthesis and thus alter the structure of the cytoplasmic membrane as well as the function of several membrane-bound enzymes like those involved in nutrient transport and chitin synthesis
  4.    all of these
Explanation:-
Answer: Option D. -> all of these
Question 10. . Which of the following drugs involves modification of the drug by enzymatic modification or degradation of its active element to alter its/their resistance?
  1.    Pencillins
  2.    Choloramphenicol
  3.    Aminoglyosides
  4.    All of these
Explanation:-
Answer: Option D. -> All of these
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