Antibody(Microbiology ) Questions and Answers

Question 1.  The class of immunoglobulins which can cross the placenta is
  1.    IgM
  2.    IgG
  3.    IgA
  4.    IgD
Explanation:-
Answer: Option B. -> IgG
Question 2.  Antigen binding sites of an immunoglobulin are located in
  1.    light chain alone
  2.    heavy chain alone
  3.    Fc region of the antibody
  4.    Fab regions of the antibody
Explanation:-
Answer: Option D. -> Fab regions of the antibody
Question 3.  Which of the following mediates Type I hypersensitivity reaction?
  1.    IgE
  2.    IgG
  3.    IgM
  4.    IgD
Explanation:-
Answer: Option A. -> IgE
Question 4.  
Simulation of which of the following will lead to appearance of first antibody to appear following stimulation by an antigen?
  1.    IgM
  2.    IgA
  3.    IgE
  4.    IgG
Explanation:-
Answer: Option A. -> IgM
Question 5.  Self reactive antibodies are not found in significant concentration in normal serum because
  1.    it is impossible to generate a self-reactive antibody
  2.    self reactive B cells are killed by CD8 T cells
  3.    B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
  4.    self reactive B cells switch to IgA which is all secreted and not present in serum
Explanation:-
Answer: Option C. -> B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
Question 6.  Which of the following theory of antibody production is most widely accepted?
  1.    Side chain theory
  2.    Clonal selection theory
  3.    Direct template theory
  4.    Indirect template theory
Explanation:-
Answer: Option B. -> Clonal selection theory
Question 7.  Which is the most efficient complement fixing class of antibody?
  1.    IgE
  2.    IgA
  3.    IgM
  4.    IgG
Explanation:-
Answer: Option C. -> IgM
Question 8.  The class of immunoglobulin, most abundant in body is
  1.    IgD
  2.    IgE
  3.    IgG
  4.    IgM
Explanation:-
Answer: Option C. -> IgG
Question 9. . J chain is present in
  1.    IgA
  2.    IgM
  3.    Both (a) and (b)
  4.    IgE
Explanation:-
Answer: Option C. -> Both (a) and (b)
Question 10. . Heat-labile class of immunoglobulins include
  1.    IgA
  2.    IgE
  3.    IgG
  4.    IgM
Explanation:-
Answer: Option B. -> IgE
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