Disease Associated With Immune System(Biochemistry ) Questions and Answers

Question 1. The HIV virus infects primarily
  1.    liver cells
  2.    brain cells
  3.    cells in the immune system
  4.    red blood cells
Explanation:-
Answer: Option C. -> cells in the immune system
Question 2. Difficulties with somatic gene therapy arise from all of the following except
  1.    inserting a gene so that it will function properly
  2.    GVHD caused by mature T cells in the transplanted cells
  3.    transducing genetic material into stem cells
  4.    limited life span of more mature hematopoietic cells
Explanation:-
Answer: Option B. -> GVHD caused by mature T cells in the transplanted cells
Question 3. Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
  1.    infected cell processing of virus peptides
  2.    CTL killing of viruses
  3.    dendritic cell activation to become a mature APC
  4.    macrophage intracellular killing of bacteria
Explanation:-
Answer: Option D. -> macrophage intracellular killing of bacteria
Question 4. Retinoblastoma is due to a mutation in a
  1.    kinase
  2.    viral gene
  3.    cyclin
  4.    tumor supressor
Explanation:-
Answer: Option D. -> tumor supressor
Question 5. A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind
  1.    Tyr or Phe
  2.    Ser or Thr
  3.    Leu or Ileu
  4.    His or Pro
Explanation:-
Answer: Option A. -> Tyr or Phe
Question 6. To treat HIV infections using drugs, the major problem is that
  1.    the virus particles with altered (mutant) proteases arise
  2.    the drugs are rapidly degraded
  3.    the drugs that are good inhibitors cannot by synthesized
  4.    the drugs interfere with normal digestion
Explanation:-
Answer: Option A. -> the virus particles with altered (mutant) proteases arise
Question 7. If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced
  1.    IgG synthesis
  2.    macrophage activation to vesicular pathogens
  3.    alternative complement activation.
  4.    CD8 T cell-mediated cytotoxicity
Explanation:-
Answer: Option C. -> alternative complement activation.
Question 8. The primary reason for AIDS, a deadly disease is that it
  1.    causes a breakdown of the body's inflammatory response
  2.    is caused by a bacterium
  3.    is caused by a virus
  4.    destroys key components of the body's internal defense system
Explanation:-
Answer: Option D. -> destroys key components of the body's internal defense system
Question 9. Specific translocations are associated with
  1.    some leukemias
  2.    breast cancer
  3.    colon cancer
  4.    pancreatic cancer
Explanation:-
Answer: Option A. -> some leukemias
Question 10. An autoimmune disease is
  1.    AIDS
  2.    Lupus
  3.    Mumps
  4.    Measles
Explanation:-
Answer: Option B. -> Lupus
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