Monoclonal Antibodies(Biotechnology ) Questions and Answers

Question 1. The cross linkage of antigens by antibodies is known as
  1.    all of these
  2.    agglutination
  3.    complement fixation
  4.    a cross reaction
Explanation:-
Answer: Option B. -> agglutination
Question 2. Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with
  1.    IgA
  2.    IgE
  3.    IgG
  4.    Ig MAbs
Explanation:-
Answer: Option D. -> Ig MAbs
Question 3. In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a
  1.    lymphoblast
  2.    natural killer cell
  3.    myeloma
  4.    hybridoma
Explanation:-
Answer: Option D. -> hybridoma
Question 4. The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as
  1.    all of these
  2.    combination of EB Vand hybridoma techniques
  3.    transformation of antigen specific B lymphocytes (EBV)
  4.    hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
Explanation:-
Answer: Option A. -> all of these
Question 5. Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the
  1.    absence of human immune response against murine proteins (HAMA) response
  2.    poor recognition of immunoglobulin, Ig constant regions
  3.    All of these
  4.    presence of HAMA response
Explanation:-
Answer: Option A. -> absence of human immune response against murine proteins (HAMA) response
Question 6. The primary B cell receptor is
  1.    IgG
  2.    IgD
  3.    IgE
  4.    IgA
Explanation:-
Answer: Option B. -> IgD
Question 7. T cells are the source of
  1.    lymphotoxin
  2.    all of these
  3.    interleukin
  4.    interferon
Explanation:-
Answer: Option B. -> all of these
Question 8. An example of mosaic antigen is
  1.    protein
  2.    a hapten
  3.    virus
  4.    bacteria
Explanation:-
Answer: Option C. -> virus
Question 9. In human B cells and T cells are matured in the
  1.    bursa and thymus respectively
  2.    lymph nodes and spleen respectively
  3.    bone marrow and thymus respectively
  4.    none of these
Explanation:-
Answer: Option C. -> bone marrow and thymus respectively
Question 10. It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at
  1.    low frequencies
  2.    moderate frequencies
  3.    at no frequency
  4.    high frequencies
Explanation:-
Answer: Option D. -> high frequencies
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