Prodrugs And Excretion Of Drugs(Drug And Pharmaceutical Biotechnology ) Questions and Answers
Question 1. Which of the following will be the pharmacokinetic application of prodrugs?
Improvement of taste
Improvement of odour
Site-specific drug delivery
Reduction in GI irritation
Explanation:-
Answer: Option C. -> Site-specific drug delivery Answer: (c).Site-specific drug delivery
Question 2. A liquid with high vapour pressure has a strong odour.
True
False
May be True or False
Can't say
Explanation:-
Answer: Option A. -> True Answer: (a).True
Question 3. How improvement of a drug in case of taste is done?
Injecting the drug so no taste related problems
Reducing the drug solubility in the saliva
Lower affinity for the taste receptors and making the drug sweet
Reducing drug solubility in saliva and lower affinity for taste receptors
Explanation:-
Answer: Option D. -> Reducing drug solubility in saliva and lower affinity for taste receptors Answer: (d).Reducing drug solubility in saliva and lower affinity for taste receptors
Question 4. Which one of the following will be an example of changing the physical form of the drug to get a prodrug?
Ethyl mercaptan to 1,3-Diesters
Trichloroethanol to p-Acetamidobenzene ester
Ethyl mercaptan to phthalate esters
Chloramphenicol to palmitate ester
Explanation:-
Answer: Option A. -> Ethyl mercaptan to 1,3-Diesters Answer: (a).Ethyl mercaptan to 1,3-Diesters
Question 5. No drug cause damage to the gastric mucosa.
True
False
May be True or False
Can't say
Explanation:-
Answer: Option B. -> False Answer: (b).False
Question 6. Which of the following will not be a limitation for prodrug design?
Formation of toxic product
An inert carrier can be cleaved off forming toxic product
Product cleaving off before reaching the target site
The cleaving of the carrier is also site-specific
Explanation:-
Answer: Option D. -> The cleaving of the carrier is also site-specific Answer: (d).The cleaving of the carrier is also site-specific
Question 7. How to prevent hepatic first-pass metabolism for corticosteroids?
Providing intravenously
Providing orally
Form esters and ether products
By enhancing lipophilicity
Explanation:-
Answer: Option C. -> Form esters and ether products Answer: (c).Form esters and ether products
Question 8. Which one of the following is the principal organ for drug excretion?
Lungs
Liver
Kidneys
Sweat glands
Explanation:-
Answer: Option C. -> Kidneys Answer: (c).Kidneys
Question 9. What is the molecular weight cut off for biliary excretion?
Less than 300 Dalton
More than 300 Dalton
Less than 200 Dalton
More than 200 Dalton
Explanation:-
Answer: Option B. -> More than 300 Dalton Answer: (b).More than 300 Dalton
Question 10. Compounds excreted in bile is classified into 3 categories. Which one of the following does not come under the categories?
Drugs with bile/plasma concentration ratio approximately 1
Drugs with bile/plasma concentration ratio between 10-1000
Drugs with bile/plasma concentration ratio of less than 1
Drugs with bile/plasma concentration ratio above 1000
Explanation:-
Answer: Option D. -> Drugs with bile/plasma concentration ratio above 1000 Answer: (d).Drugs with bile/plasma concentration ratio above 1000