Modifications And Mutagenesis(Engineering > Genetic Engineering ) Questions and Answers

Question 1. Double stranded RNA is cleaved by a nuclease called as Dicer and small fragments are generated known as ___________
  1.    short interfering RNAs
  2.    long interfering RNAs
  3.    short interspersed RNAs
  4.    long interspersed RNAs
Explanation:-
Answer: Option A. -> short interfering RNAs
Answer: (a).short interfering RNAs
Question 2. Down regulation of expression of endogenous genes by transformation with constructs that would generate sense RNA, rather than anti-sense RNA is known as ___________
  1.    suppression
  2.    co-suppression
  3.    multisuppression
  4.    anti-suppression
Explanation:-
Answer: Option B. -> co-suppression
Answer: (b).co-suppression
Question 3. In some organisms, presence of double stranded RNAs leads to breakdown of corresponding single stranded mRNA.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 4. DNA _________ is also a method for gene silencing through short RNAs.
  1.    acetylation
  2.    phosphorylation
  3.    methylation
  4.    acylation
Explanation:-
Answer: Option C. -> methylation
Answer: (c).methylation
Question 5. The process of RNA inactivation by siRNAs is termed as ___________
  1.    RNA silencing
  2.    RNA interference
  3.    Short RNA inactivation
  4.    RNA disfunction
Explanation:-
Answer: Option B. -> RNA interference
Answer: (b).RNA interference
Question 6. Choose the correct statement for self cleavage reaction.
  1.    It is nucleophilic attack reaction by 2’ hydroxyl of RNA
  2.    It is nucleophilic attack reaction by 3’ hydroxyl of RNA
  3.    It is nucleophilic attack reaction by 2’ hydroxyl of DNA
  4.    It is nucleophilic attack reaction by 3’ hydroxyl of DNA
Explanation:-
Answer: Option A. -> It is nucleophilic attack reaction by 2’ hydroxyl of RNA
Answer: (a).It is nucleophilic attack reaction by 2’ hydroxyl of RNA
Question 7. A substance that induces unregulated growth processes in cells or tissues leading to cancer are called as
  1.    mutagen
  2.    carcinogen
  3.    Pathogens
  4.    Microbes
Explanation:-
Answer: Option B. -> carcinogen
Answer: (b).carcinogen
Question 8. Self cleavage reaction can take place in?
  1.    DNA
  2.    RNA
  3.    Both DNA and RNA
  4.    Can take place in both but is preferred in DNA
Explanation:-
Answer: Option B. -> RNA
Answer: (b).RNA
Question 9. Mutagens can be
  1.    Interferes the functions of nucleotides
  2.    Physical agent
  3.    Chemical agent
  4.    all of above
Explanation:-
Answer: Option D. -> all of above
Answer: (d).all of above
Question 10. Carcinogens are always
  1.    mutagens
  2.    mutants
  3.    point mutants
  4.    silent mutant
Explanation:-
Answer: Option A. -> mutagens
Answer: (a).mutagens
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