Structural Bioinformatics(Bioinformatics ) Questions and Answers

Question 1. The building blocks of proteins are ______ naturally occurring amino acids, small molecules that contain a free amino group (NH₂) and a free carboxyl group (COOH).
  1.    ten
  2.    twenty
  3.    nine
  4.    nineteen
Explanation:-
Answer: Option B. -> twenty
Answer: (b).twenty
Question 2. Within the hydrophobic set of amino acids, they can be further divided into aliphatic and aromatic.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 3. ______ the smallest amino acid, has a hydrogen atom as the R group.
  1.    valine
  2.    proline
  3.    Glycine
  4.    threonine
Explanation:-
Answer: Option C. -> Glycine
Answer: (c).Glycine
Question 4. The peptide formation involves two amino acids covalently joined together between the carboxyl group of one amino acid and the amino group of another.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 5. A linear polymer of more than fifty amino acid residues is referred to as a ________
  1.    dipeptide
  2.    oligopeptide
  3.    peptide
  4.    polypeptide
Explanation:-
Answer: Option D. -> polypeptide
Answer: (d).polypeptide
Question 6. The early algorithms based their prediction on hydrophobicity scales.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 7. The presence of ______ signal peptides can significantly compromise the prediction _______ because the programs tend to confuse hydrophobic signal peptides with membrane helices.
  1.    hydrophobic, accuracy
  2.    hydrophobic, error
  3.    hydrophilic, accuracy
  4.    hydrophilic, error
Explanation:-
Answer: Option A. -> hydrophobic, accuracy
Answer: (a).hydrophobic, accuracy
Question 8. Predictions solely based on hydrophobicity profiles have lowest error rates.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option B. -> False
Answer: (b).False
Question 9. Which of the following is untrue regarding Phobius?
  1.    It is a web-based program designed to overcome false positives caused by the presence of signal peptides
  2.    The program incorporates distinct HMM models for signal peptides only
  3.    The program incorporates distinct HMM models for signal peptides as well as transmembrane helices
  4.    After distinguishing the putative signal peptides from the rest of the query sequence, prediction is made on the remainder of the sequence
Explanation:-
Answer: Option B. -> The program incorporates distinct HMM models for signal peptides only
Answer: (b).The program incorporates distinct HMM models for signal peptides only
Question 10. Which of the following is untrue regarding TMHMM?
  1.    It is a web-based program based on an HMM algorithm
  2.    It is trained to recognize transmembrane helical patterns
  3.    It is not trained to recognize transmembrane helical patterns
  4.    When a query sequence is scanned, the probability of having an α-helical domain is given
Explanation:-
Answer: Option C. -> It is not trained to recognize transmembrane helical patterns
Answer: (c).It is not trained to recognize transmembrane helical patterns
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