Biotransformation Of Drugs(Drug And Pharmaceutical Biotechnology ) Questions and Answers

Question 1. Electrophiles are deficient of pair of electrons and free radicals contain an odd number of electrons.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 2. What is the body’s defence against electrophiles?
  1.    Their inactivation by conjugation with glucagon
  2.    Their inactivation by conjugation with glutamine
  3.    Their inactivation by conjugation with glucuronic acid
  4.    Their inactivation by conjugation with glutathione
Explanation:-
Answer: Option D. -> Their inactivation by conjugation with glutathione
Answer: (d).Their inactivation by conjugation with glutathione
Question 3. Which of the following is an example of electrophiles?
  1.    Thalidomide
  2.    Aflatoxin
  3.    Epoxides
  4.    Benzopyrene
Explanation:-
Answer: Option C. -> Epoxides
Answer: (c).Epoxides
Question 4. Which of the following statement rightly states “bioactivation”?
  1.    Formation of high reactive metabolites which interact with tissues to precipitate toxic compounds
  2.    Formation chelating agents
  3.    Formation of enzymes which can lyse toxic compounds
  4.    Stimulating the immune systems to initiate the formation of t cells
Explanation:-
Answer: Option A. -> Formation of high reactive metabolites which interact with tissues to precipitate toxic compounds
Answer: (a).Formation of high reactive metabolites which interact with tissues to precipitate toxic compounds
Question 5. Which xenobiotics yield free radicles on metabolic activation?
  1.    Thalidomide
  2.    Aflatoxin
  3.    Quinones
  4.    Benzopyrene
Explanation:-
Answer: Option C. -> Quinones
Answer: (c).Quinones
Question 6. Which of the following will be an example of inorganic free radicle?
  1.    H₂O₂ and O₂⁻
  2.    Aflatoxin
  3.    Quinones
  4.    Benzopyrene
Explanation:-
Answer: Option A. -> H₂O₂ and O₂⁻
Answer: (a).H₂O₂ and O₂⁻
Question 7. Bioavailability of glutathione in the body doesn’t determine the threshold of a toxic response.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option B. -> False
Answer: (b).False
Question 8. How are free radicals generated in the human body?
  1.    Through cytochrome P-450 system
  2.    NADPH cytochrome P-450 reductase
  3.    NADPH reductase
  4.    Through cytochrome P-350 system
Explanation:-
Answer: Option B. -> NADPH cytochrome P-450 reductase
Answer: (b).NADPH cytochrome P-450 reductase
Question 9. How are electrophiles generated?
  1.    Through cytochrome P-450 system
  2.    NADPH cytochrome P-450 reductase
  3.    Different Flavin containing reductase
  4.    Through cytochrome P-350 system
Explanation:-
Answer: Option A. -> Through cytochrome P-450 system
Answer: (a).Through cytochrome P-450 system
Question 10. Free radicals are more dangerous than electrophiles.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
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