Protein Binding Of Drugs(Drug And Pharmaceutical Biotechnology ) Questions and Answers

Question 1. Which of the following drugs accumulate in skin?
  1.    Acidic drugs like imipramine
  2.    Basic drugs like imipramine
  3.    Halogenated hydrocarbons
  4.    Chloroquine
Explanation:-
Answer: Option D. -> Chloroquine
Answer: (d).Chloroquine
Question 2. Which drugs deposit in hair shafts?
  1.    Arsenicals
  2.    Tetracycline
  3.    Halogenated hydrocarbons
  4.    Lipophilic drug
Explanation:-
Answer: Option A. -> Arsenicals
Answer: (a).Arsenicals
Question 3. Which drug accumulate in adipose tissue?
  1.    Arsenicals
  2.    Tetracycline
  3.    Halogenated hydrocarbons
  4.    Lipophilic drug
Explanation:-
Answer: Option D. -> Lipophilic drug
Answer: (d).Lipophilic drug
Question 4. Which of the following drugs are responsible for retinopathy?
  1.    Acidic drugs like imipramine
  2.    Basic drugs like imipramine
  3.    Halogenated hydrocarbons
  4.    Chloroquinine
Explanation:-
Answer: Option D. -> Chloroquinine
Answer: (d).Chloroquinine
Question 5. Which drug causes brown yellow discoloration of infant’s teeth?
  1.    Arsenicals
  2.    Tetracycline
  3.    Halogenated hydrocarbons
  4.    Lipophilic drug
Explanation:-
Answer: Option B. -> Tetracycline
Answer: (b).Tetracycline
Question 6. What kind of graph is shown in the picture?What Kind Of Graph Is Shown In The Picture?
  1.    Direct plot
  2.    Scatchard plot
  3.    Double reciprocal plot
  4.    Michele’s menten plot
Explanation:-
Answer: Option C. -> Double reciprocal plot
Answer: (c).Double reciprocal plot
Question 7. Which one of the following bonds is not generally a bond through which a drug will bind in our body?
  1.    Hydrogen bond
  2.    Hydrophobic bond
  3.    Ionic bond
  4.    Covalent bond
Explanation:-
Answer: Option D. -> Covalent bond
Answer: (d).Covalent bond
Question 8. Which one of the following is the correct order of the drugs binding to various plasma protein?
  1.    Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins
  2.    Albumin > globulins > lipoproteins > alpha-1 acid glycoprotein
  3.    Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
  4.    Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein
Explanation:-
Answer: Option C. -> Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
Answer: (c).Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
Question 9. Binding of drugs falls into 2 components those are _______________
  1.    Binding of drugs to blood components and to extravascular tissue
  2.    Binding of drugs to blood components and to other cells
  3.    Binding of drugs to cells and blood cells
  4.    Binding of drugs to blood components to bones and cells
Explanation:-
Answer: Option A. -> Binding of drugs to blood components and to extravascular tissue
Answer: (a).Binding of drugs to blood components and to extravascular tissue
Question 10. What is the molecular weight of human serum albumin?
  1.    5000 Dalton
  2.    65,000 Dalton
  3.    60,000 Dalton
  4.    75,000 Dalton
Explanation:-
Answer: Option B. -> 65,000 Dalton
Answer: (b).65,000 Dalton
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