Pharmacokinetic Drug Interactions(Drug And Pharmaceutical Biotechnology ) Questions and Answers

Question 1. Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option B. -> False
Answer: (b).False
Question 2. The time period for which the plasma concentration of drug remains above minimum effective concentration is known as ______________
  1.    Onset of time
  2.    Onset of action
  3.    Duration of drug of action
  4.    Therapeutic range
Explanation:-
Answer: Option C. -> Duration of drug of action
Answer: (c).Duration of drug of action
Question 3. Haemodialysis is also known as extracorporeal dialysis.
  1.    True
  2.    False
  3.    May be True or False
  4.    Can't say
Explanation:-
Answer: Option A. -> True
Answer: (a).True
Question 4. Which of the following will not be a factor governing the removal of substances through dialysis?
  1.    Molecular weight
  2.    Water solubility
  3.    Disintegration time
  4.    Protein binding
Explanation:-
Answer: Option C. -> Disintegration time
Answer: (c).Disintegration time
Question 5. Which kind of membrane is used in haemodialysis?
  1.    Artificial Semipermeable membrane
  2.    Permeable membrane
  3.    Natural semipermeable membrane of the peritoneal cavity
  4.    Artificial permeable membrane
Explanation:-
Answer: Option A. -> Artificial Semipermeable membrane
Answer: (a).Artificial Semipermeable membrane
Question 6. Which of the following is not a characteristic of the caternary compartment model?
  1.    It gives a visual representation of various rate processes in drug disposition
  2.    It shows how many rate constants are necessary
  3.    Compartments and parameters bear a relationship with physiologic functions
  4.    Useful in predicting drug
Explanation:-
Answer: Option C. -> Compartments and parameters bear a relationship with physiologic functions
Answer: (c).Compartments and parameters bear a relationship with physiologic functions
Question 7. In noncompartmental analysis, Mean residence time is equal to _____________
  1.    The area under the first moment curve/area under the zero moment curve
  2.    The area under the zero moment’s curve/area under the first moment curve
  3.    1 / Area under the first-moment curve
  4.    1/ Area under the zero moment curve
Explanation:-
Answer: Option A. -> The area under the first moment curve/area under the zero moment curve
Answer: (a).The area under the first moment curve/area under the zero moment curve
Question 8. Which model is also known as membrane permeation rate limited?
  1.    Physiologic model
  2.    Compartment model
  3.    Noncompartment model
  4.    Mammillary model
Explanation:-
Answer: Option A. -> Physiologic model
Answer: (a).Physiologic model
Question 9. Which of the following will be a disadvantage for the physiologic model?
  1.    Prediction of drug concentration in various body regions
  2.    Correlation of data in several animal species
  3.    Obtaining experimental data for each of the organs
  4.    The model gives an exact description of the drug concentration-time profile for any organ
Explanation:-
Answer: Option C. -> Obtaining experimental data for each of the organs
Answer: (c).Obtaining experimental data for each of the organs
Question 10. Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data?
  1.    Compartment model
  2.    Caternary model
  3.    Physiologic model
  4.    Mammillary model
Explanation:-
Answer: Option C. -> Physiologic model
Answer: (c).Physiologic model
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